MNS

MedChem Express

MNS [1485-00-3]

10

1485-00-3

Research Use Only

99.60

C9H7NO4

193.16

MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS inhibits Src, Syk, and FAK with IC 50 of 27.3, 2.8, and 97.6 microM, respectively. MNS inhibits NLRP3 inflammasome and beta1 integrin . MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC 50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 microM, respectively. MNS is cytotoxic to a variety of cells [1] [2] [3] [4] [5] [6] [7] [8] [9] .

O=[N+]([O-])/C=C/C1=CC(OCO2)=C2C=C1

-20°C,2°C to 8°C

12352200