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ProductsBack/MnTBAP chloride [55266-18-7]
Chemical Structure
Chemical Structure
Chemical Structure

MnTBAP chloride [55266-18-7]

Research Use Only
AG-CR1-0133
AdipoGen Life Sciences
CAS Number55266-18-7
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight879.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    MnTBAP chloride [55266-18-7]
  • Delivery Days Customer
    10
  • CAS Number
    55266-18-7
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Molecular Formula
    C48H28MnN4O8Cl
  • Molecular Weight
    879.2
  • Scientific Description
    Cell permeable superoxide dismutase (SOD) mimetic [1, 2]. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO) [3]. Neuronal apoptosis inhibitor [4]. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death [5]. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK [6]. . - Chemical. CAS: 55266-18-7. Formula: C48H28MnN4O8Cl. MW: 879.2. Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Neuronal apoptosis inhibitor. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK. .
  • SMILES
    [Cl-].OC(=O)C1=CC=C(C=C1)C1=C2C=CC3=C(C4C=CC5=C(C6=CC=C7N6[Mn+3](N6C1C=CC6=C7C1=CC=C(C=C1)C(O)=O)(N45)N23)C1=CC=C(C=C1)C(O)=O)C1=CC=C(C=C1)C(O)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994)
  • A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther. 275,1227 (1995)
  • Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabe;, et al.; FEBS Lett. 381, 82 (1996)
  • Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic: M. Patel; J. Neurochem. 71, 1068 (1998)
  • Reactive oxygen species regulate activation-induced T cell apoptosis: D.A. Hildeman, et al.; Immunity 10, 735 (1999)
  • MnTBAP, a synthetic metalloporphyrin, inhibits production of tumor necrosis factor-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages cells via inhibiting oxidative stress-mediating p38 and SAPK/JNK signaling: G. Tumurkhuu, et al.; FEMS Immunol. Med. Microbiol. 49, 304 (2007)
  • Regulation of Beclin 1 protein phosphorylation and autophagy by protein phosphatase 2A (PP2A) and death-associated protein kinase 3 (DAPK3): N. Fujiwara, et al.; J. Biol. Chem. 291, 10858 (2016)