Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA872519HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA872519HA01HU at dilution of 1:100
MOB1A Antibody
CSB-PA872519HA01HU
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetMOB1A
Overview
- SupplierCusabio
- Product NameMOB1A Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID55233
- Target nameMOB1A
- Target descriptionMOB kinase activator 1A
- Target synonymsC2orf6; MABKL1B; MATS1; MOB kinase activator 1A; MOB1; mob1 alpha; mob1 homolog 1B; MOB1 Mps One Binder homolog A; MOB1, Mps One Binder kinase activator-like 1B; Mob4B; MOBK1B; MOBKL1B; mps one binder kinase activator-like 1B
- HostRabbit
- IsotypeIgG
- Protein IDQ9H8S9
- Protein NameMOB kinase activator 1A
- Scientific DescriptionActivator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203