Moexiprilat

Biorbyt

Moexiprilat

10

103775-14-0

Research Use Only

98.00%

C25H30N2O7

470.51

Moexiprilat, an active metabolite of the prodrug moexipril formed through side chain ester hydrolysis in vivo, functions as an angiotensin-converting enzyme (ACE; IC50 = 2.1 nM) inhibitor. At a concentration of 10 nM, it inhibits the proliferation of primary neonatal rat cardiac fibroblasts stimulated by estrone or angiotensin II. Furthermore, when given at a daily dosage of 50 mg/kg, moexiprilat reduces mean arterial blood pressure and elevates levels of atrial natriuretic peptide, an indicator of hypertension, in ovariectomized mice.

C[C@H](N[C@H](C(O)=O)CCC1=CC=CC=C1)C(N2CC3=CC(OC)=C(OC)C=C3C[C@H]2C(O)=O)=O

-20°C

12352200