Monomethyl auristatin E [474645-27-7]

MedChem Express

Monomethyl auristatin E [474645-27-7]

10

474645-27-7

Research Use Only

99.98

h300+h330, h340, h360, h370, h372, h412

C39H67N5O7

717.98

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

CC(C)[C@H](NC)C(N[C@@H](C(C)C)C(N(C)[C@H]([C@@H](CC(N1[C@]([C@H](OC)[C@H](C(N[C@@H]([C@H](C2=CC=CC=C2)O)C)=O)C)(CCC1)[H])=O)OC)[C@H](CC)C)=O)=O

-20°C

41115800