MORF-627

MedChem Express

MORF-627 [2412688-16-3]

5

Research Use Only

C31H40FN3O4

537.67

MORF-627 is a selective, orally active inhibitor for integrin alphavbeta6 with an IC50 of 9.2 nM measuring by human serum ligand binding assay. MORF-627 inhibits alphavbeta6-mediated TGF-beta1 activation with an IC50 of 2.63 nM, inhibits SMAD2/3 phosphorylation with an IC50 of 8.3 nM. MORF-627 ameliorates the Bleomycin (HY-108345)-induced mouse lung fibrosis[1].

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