Mouse CD254 / RANKL recombinant protein (Active) (His-tagged, C-ter)

Arigo Biolaboratories

Mouse CD254 / RANKL recombinant protein (Active) (His-tagged, C-ter)

23

Other Application

Research Use Only

>98%

Tnfsf11

tumor necrosis factor (ligand) superfamily, member 11

Ly109l, ODF, OPGL, RANKL, Trance, tumor necrosis factor ligand superfamily member 11, OPG ligand, TNF-related activation-induced cytokine, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of NF-kappaB ligand, receptor activator of nuclear factor kappa-B ligand, tumor necrosis factor-related activation-induced cytokine

Tumor necrosis factor ligand superfamily member 11

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

-20°C

41116120

Mouse