Mouse CD274 / PD-L1 ELISA Kit

Arigo Biolaboratories

Mouse CD274 / PD-L1 ELISA Kit

23

ELISA

Intra-Assay CV: 6.7%; Inter-Assay CV: 7.5%

15.6 pg/ml

There is no detectable cross-reactivity with other relevant proteins.

~ 5 hours

Research Use Only

CD274 / PD-L1 is an immune inhibitory receptor ligand. It is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

2°C to 8°C

41116133