Mouse CTLA4 protein, mutant mouse IgG2a Fc tag (active)

GeneTex

Mouse CTLA4 + Mouse IgG2a Fc fusion protein (non-lytic)

9

Blocks the binding of mouse CD80 (B7-1) and CD86 (B7-2) to their receptors (by binding CD80 and CD86 with high affinity) and thereby prevents their T cell regulatory actions by inhibiting the CD28 signaling competitively. Shows the biological functions of the CD152 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Useful for investigating the T cell co-stimulation.

Functional Assay

Research Use Only

Unconjugated

Lyophilized

-20°C

12352202