Mouse IL15 / IL15R Complex ELISA Kit

Arigo Biolaboratories

Mouse IL15 / IL15R Complex ELISA Kit

23

ELISA

Intra-Assay CV: 4.6%Inter-Assay CV: 3.5%

7.8 pg/ml

This kit could assay both natural and recombinant Mouse IL15 / IL15R Complex.No significant cross-reactivity or interference was observed in the following samples:Human: IFN gamma, IL1 beta, IL2, IL4, IL5, IL6, IL8, IL10, IL12, IL17A, IL18, IL21, IL22, IL

~ 2.5 hours

Research Use Only

The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each others activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

2°C to 8°C

41116133