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Mouse IL33 ELISA Kit

ARG80228
Arigo Biolaboratories
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    Mouse IL33 ELISA Kit
  • Delivery Days Customer
    23
  • Applications
    ELISA
  • Assay Precision
    CV:
  • Assay Sensitivity
    24 pg/ml
  • Assay Specificity
    No significant cross-reactivity or interference with Mouse Pro-IL-33 (aa 1-108), ST2/IL-1 R4/Fc Chimera
  • Assay Time
    4 hours
  • Certification
    Research Use Only
  • Scientific Description
    Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1alphabeta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-kappaB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116133

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