Mouse IL5 ELISA kit

Arigo Biolaboratories

Mouse IL5 ELISA kit

23

ELISA

CV:

8 pg/ml

No significant cross-reactivity or interference with GM-CSF, IL3, IL5Ralpha.

4 hours

Research Use Only

The IL-5 gene is located on chromosome 11 in the mouse, and chromosome 5 in humans, in close proximity to the genes encoding IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in TH2 cells. Interleukin-5 is also expressed by eosinophils[4] and has been observed in the mast cells of asthmatic airways by immunohistochemistry. IL-5 expression is regulated by several transcription factors including GATA3. [IL-5 wiki] IL5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL5 plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of IL5 may be related to pathogenesis of eosinophil-dependent inflammatory diseases. IL5 functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). [provided by RefSeq, Jul 2013]

2°C to 8°C

41116133