Mouse IL6 protein, His tag (active)

GeneTex

Mouse IL6 protein (active)

9

Interleukin-6 (IL-6), a pro-inflammatory cytokine and an anti-inflammatory myokine, plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It has been reported that IL6 induces C-reactive protein (CRP) expression through the STAT3 pathway in HepG2 cells. To test this effect, HepG2 cells were seeded overnight at a density of 1x105 cells/ml, and treated with or without various concentrations of IL6 for 24h and CRP levels in the cell supernatant were determined by ELISA. CRP levels in the cell supernatant of HepG2 cells increased significantly after stimulated with IL6.

Functional Assay

Research Use Only

Unconjugated

Interleukin-6

This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

-20°C or -80°C,2°C to 8°C

12352202