Mouse MEP1B / Meprin Beta ELISA Kit

Arigo Biolaboratories

Mouse MEP1B / Meprin Beta ELISA Kit

23

ELISA

Intra-Assay CV: less than 10%Inter-Assay CV: less than 10%

10 pg/ml

3.5 hours

Research Use Only

HRP

Meprin A subunit beta

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

2°C to 8°C

41116100

Human