Anti-ABRA1 Purified

EXBIO

Anti-ABRA1 Purified

7

Flow cytometry: Recommended dilution: 1-2 microg/ml. Intracellular staining. Western blotting: Reducing conditions.

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

ABRA1-01

1 mg/ml

IgG2a

ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.

Human

2°C to 8°C

12352203