Anti-Hu CD105 Purified

EXBIO

Anti-Hu CD105 Purified

7

Flow cytometry: Recommended dilution: 1-5 microg/ml. Western blotting: Non-reducing conditions.

Flow Cytometry, ImmunoPrecipitation, Western Blot, Other Application

Research Use Only

MEM-226

1 mg/ml

IgG2a

CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.

Human, Rat

2°C to 8°C

12352203