Anti-Hu CD105 Biotin
1B-453
ApplicationsFlow Cytometry, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityCanine, Equine, Human, Porcine
Overview
- SupplierEXBIO
- Product NameAnti-Hu CD105 Biotin
- Delivery Days Customer7
- Application Supplier NoteFlow cytometry: Recommended dilution: 8 microg/ml; positive control: Kg1 human acute myelogenous leukemia cell line.
- ApplicationsFlow Cytometry, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- Clone IDMEM-229
- Concentration1 mg/ml
- ConjugateBiotin
- IsotypeIgG2a
- Scientific DescriptionCD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
- ReactivityCanine, Equine, Human, Porcine
- Storage Instruction2°C to 8°C
- UNSPSC12352203