Anti-Hu CD107b Purified Azide Free

EXBIO

Anti-Hu CD107b Purified Azide Free

7

Flow cytometry: Intracellular and extracellular staining; recommended dilution: 1-2 microg/ml. Immunohistochemistry: Recommended dilution: 2-8 microg/ml. Western blotting: Recommended dilution: 1-2 microg/ml.

Flow Cytometry, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

H4B4

1 mg/ml

IgG1

CD107b (lysosome-associated membrane protein-2, LAMP-2), together with CD107a / LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa.

2°C to 8°C

12352203