Anti-Hu CD11b Biotin

EXBIO

Anti-Hu CD11b Biotin

7

Flow cytometry: Recommended dilution: 1-2 microg/ml; positive control: peripheral blood lymphocytes.

Flow Cytometry, ImmunoPrecipitation

Research Use Only

MEM-174

1 mg/ml

Biotin

IgG2a

CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.

Human

2°C to 8°C

12352203