Anti-Hu CD2 Purified

EXBIO

Anti-Hu CD2 Purified

7

Flow cytometry: Recommended dilution: 1-4 microg/ml.

Flow Cytometry, ImmunoPrecipitation

Research Use Only

MEM-65

1 mg/ml

IgG1

CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.

Human

2°C to 8°C

12352203