Anti-Hu CD22 Purified

EXBIO

Anti-Hu CD22 Purified

7

Flow cytometry: Recommended dilution: 2-4 microg/ml. Western blotting: Recommended dilution: 1-2 microg/ml, non-reducing conditions. The antibody MEM-01 stains only the higher Mw isoform (140 kDa, migrating sometimes as a 125 kDa band) and not the lower Mw isoform (130 kDa, migrating sometimes as a 115 kDa band).

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

MEM-01

1 mg/ml

IgG1

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Human, Primate

2°C to 8°C

12352203