Anti-Hu CD264 Purified Azide Free

EXBIO

Anti-Hu CD264 Purified Azide Free

7

Flow cytometry: Recommended dilution: 1-4 microg/ml.

Flow Cytometry

Research Use Only

TRAIL-R4-01

1 mg/ml

IgG1

TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).

2°C to 8°C

12352203