Anti-Hu CD50 Biotin

EXBIO

Anti-Hu CD50 Biotin

7

Flow cytometry: Recommended dilution: 3-5 microg/ml.

Flow Cytometry, ImmunoPrecipitation

Research Use Only

MEM-171

1 mg/ml

Biotin

IgG1

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.

Human

2°C to 8°C

12352203