Anti-Hu CD59 Purified

EXBIO

Mouse Monoclonal to CD59 / Protectin

7

The antibody MEM-43/5 reacts with well defined epitope (around L33) on CD59 (Protectin), a 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored extracellular glycoprotein expressed on the surface of all hematopoietic cells; it is widely present on cells

Flow cytometry: Recommended dilution: 0.5-4 microg/ml; positive control: blood. Immunohistochemistry (paraffin sections): Recommended dilution: 5 microg/ml. Western blotting: Recommended dilution: 1-2 microg/ml; positive control: mouse spleen, non-reducing conditions.

Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

MEM-43/5

1 mg/ml

IgG2b

CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.

Human, Mouse

2°C to 8°C

12352203