Anti-Hu CD62P Purified Low Endotoxin

EXBIO

Mouse Monoclonal to CD62P / P-selectin

7

The antibody AK4 recognizes an extracellular epitope of CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is

Functional application: Blocking. Flow cytometry: Recommended dilution: 1.5 microg/ml.

Functional Assay, Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

AK4

1 mg/ml

IgG1

CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.

Human, Primate

2°C to 8°C

12352203