Anti-Hu CD72 Purified

EXBIO

Anti-Hu CD72 Purified

7

Flow cytometry: Recommended dilution: 1 microg/ml.

Flow Cytometry, ImmunoPrecipitation

Research Use Only

3F3

1 mg/ml

IgG2b

CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.

Human

2°C to 8°C

12352203