Anti-Hu CD79a Purified

EXBIO

Anti-Hu CD79a Purified

7

Flow cytometry: Recommended dilution: 5 microg/ml. Intracellular staining. Immunohistochemistry (paraffin sections): Recommended dilution: 10 microg/ml. Immunohistochemistry (frozen sections): Recommended dilution: 10 microg/ml.

Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

HM57

1 mg/ml

IgG1

CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.

Bovine, Chicken, Equine, Guinea Pig, Human, Mouse, Opossum, Porcine, Rabbit, Rat

2°C to 8°C

12352203