Anti-Hu CD95 Purified

EXBIO

Anti-Hu CD95 Purified

7

Flow cytometry: Recommended dilution: 1-12 microg/ml. Excellent. Immunohistochemistry (paraffin sections): Positive tissue: tonsil.

Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

LT95

1 mg/ml

IgG1

CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.

Human

2°C to 8°C

12352203