Anti-FoxP3 APC

EXBIO

Anti-FoxP3 APC

7

Flow cytometry: Recommended dilution: 1-2 microg/ml. Intracellular staining

Flow Cytometry

Research Use Only

3G3

0.5 mg/ml

APC (Allophycocyanin)

IgG1

FoxP3 (forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.

Human, Mouse

2°C to 8°C

12352203