Anti-LAT Purified

EXBIO

Anti-LAT Purified

7

Immunoprecipitation: Tyrosine-phosphorylated form of LAT is not optimally recognized. Flow cytometry: Recommended dilution: 1-4 microg/ml, intracellular staining. Tyrosine-phosphorylated form of LAT is not optimally recognized. Western blotting: Recommended dilution: 1-2 microg/ml.

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

LAT-01

1 mg/ml

IgG1

LAT (linker for activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.

Human, Mouse

2°C to 8°C

12352203