Anti-SHIP1 Purified

EXBIO

Anti-SHIP1 Purified

7

Flow cytometry: Intracellular staining; recommended dilution: 2-5 microg/ml; positive control: human blood leukocytes. Western blotting: Positive control: RAMOS human cell line, reducing conditions.

Flow Cytometry, Western Blot, ImmunoCytoChemistry

Research Use Only

SHIP-02

1 mg/ml

IgG2a

SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI(3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcgammaRIIB, Fcgamma RIII, FcepsilonRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.

Human

2°C to 8°C

12352203