Anti-SIT Purified

EXBIO

Anti-SIT Purified

7

Flow cytometry: Recommended dilution: 1-5 microg/ml, intracellular staining. Western blotting: Recommended dilution: 1-2 microg/ml, reducing conditions.

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

SIT-01

1 mg/ml

IgG1

SIT is a 21 kDa transmembrane adaptor protein expressed exclusively in lymphoid organs. It acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.

Human

2°C to 8°C

12352203