Anti-SOS Purified
11-522
ApplicationsWestern Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Primate
Overview
- SupplierEXBIO
- Product NameAnti-SOS Purified
- Delivery Days Customer7
- Application Supplier NoteWestern blotting: Recommended dilution: 1 microg/ml; positive control: HeLa human cervix carcinoma cell line, reducing conditions.
- ApplicationsWestern Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- Clone IDSOS-01
- Concentration1 mg/ml
- IsotypeIgG1
- Scientific DescriptionThe guanine nucleotide exchange factor Sos (son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization; the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.
- ReactivityHuman, Mouse, Primate
- Storage Instruction2°C to 8°C
- UNSPSC12352203