Mouse TMEM106B Protein (TEM-MM26B)

KACTUS

Mouse TMEM106B Protein (TEM-MM26B)

9

>95%

Transmembrane protein 106B

TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).

-20°C or -80°C,-80°C

12352202