Mouse Transglutaminase 2 Ready-To-Use IHC Kit

Bioss

Mouse Transglutaminase 2 Ready-To-Use IHC Kit

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ImmunoHistoChemistry

Research Use Only

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimers disease brain, the elevated tTGase activity is manifested by polymerization ofa number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.

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