mPGES1-IN-7 [1268709-57-4]

MedChem Express

mPGES1-IN-7 [1268709-57-4]

5

1268709-57-4

Research Use Only

99.78

C23H34N4O

382.54

mPGES-1-IN-2 (compound III) is a benzimidazole-based mPGES-1 inhibitor that also inhibits adipophysin PGD synthase (I-PGDS) (5 microM, IR=60 %). mPGES-1-IN-2 reduces PGE2 production and tends to reduce levels of other prostaglandins. mPGES-1-IN-2 effectively inhibits acute inflammation in an air sac model stimulated by Carrageenan (HY-125474) in mice[1].

O=C(NC1CCCC1)C2CCN(CC2)C3=NC4=CC(C)=C(C=C4N3C(C)C)C

-20°C,2°C to 8°C

12352200