MPP+ (iodide)

MedChem Express

MPP+ (iodide) [36913-39-0]

5

36913-39-0

Research Use Only

99.94

C12H12IN

297.14

MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinsons disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) [1] [2] .

C[N+]1=CC=C(C2=CC=CC=C2)C=C1.[I-]

2°C to 8°C

12352200