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MPST antibody [C2C3], C-term

GTX108274
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetMPST
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Overview

  • Supplier
    GeneTex
  • Product Name
    MPST antibody [C2C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.57 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4357
  • Target name
    MPST
  • Target description
    mercaptopyruvate sulfurtransferase
  • Target synonyms
    3-mercaptopyruvate sulfurtransferase; human liver rhodanese; MST; testicular tissue protein Li 200; tRNA thiouridin modification protein 1; TST2; TUM1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP25325
  • Protein Name
    3-mercaptopyruvate sulfurtransferase
  • Scientific Description
    This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Hypoxia-Induced Changes in L-Cysteine Metabolism and Antioxidative Processes in Melanoma Cells.
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  • MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT. Zhang J et al., 2022 Oct, Redox Biol
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  • Sulfurtransferases and Cystathionine Beta-Synthase Expression in Different Human Leukemia Cell Lines. Jurkowska H et al., 2022 Jan 18, Biomolecules
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  • Effect of S-Allyl -L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis. Bronowicka-Adamska P et al., 2020 Feb 6, Int J Mol Sci
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  • Dysregulation of cystathionine gamma-lyase promotes prostate cancer progression and metastasis. Wang YH et al., 2019 Oct 4, EMBO Rep
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  • New aspects of antiproliferative activity of 4-hydroxybenzyl isothiocyanate, a natural H2S-donor. Jurkowska H et al., 2018 Jun, Amino Acids
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  • Hydrogen sulfide generation from l-cysteine in the human glioblastoma-astrocytoma U-87 MG and neuroblastoma SHSY5Y cell lines. Bronowicka-Adamska P et al., 2017, Acta Biochim Pol
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