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MPT0G211 [2151853-97-1]

MPT0G211 [2151853-97-1]

T60616
TargetMol Chemicals
CAS Number2151853-97-1
DownloadMSDS
Product group Chemicals
Estimated Purity99.91%
Molecular Weight293.32
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    MPT0G211 [2151853-97-1]
  • Delivery Days Customer
    10
  • CAS Number
    2151853-97-1
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    MPT0G211
  • Estimated Purity
    99.91%
  • Molecular Formula
    C17H15N3O2
  • Molecular Weight
    293.32
  • Scientific Description
    MPT0G211 is a highly selective and orally active HDAC6 inhibitor (IC50=0.291 nM) that has neuroprotective effects and has shown anti-metastatic activity in human breast cancer cells. MPT0G211 has 1,000 times more affinity for HDAC6 than other HDAC subtypes. MPT0G211 can cross the blood-brain barrier and could be used to improve tau phosphorylation and cognitive deficits in Alzheimers disease models.
  • Shelf life instruction
    3 years
  • SMILES
    ONC(=O)c1ccc(CNc2cccc3cccnc23)cc1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells. Tu HJ et al., 2018 Dec 29, Clin Epigenetics
    Read more

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