MR-16728 (hydrochloride) [207403-36-9]

MedChem Express

MR-16728 (hydrochloride) [207403-36-9]

9

207403-36-9

Research Use Only

C23H37ClN2O

393.01

MR-16728 hydrochloride is a compound that promotes the release of acetylcholine and has activity that enhances the release of acetylcholine. MR-16728 hydrochloride inhibits acetylcholine release induced by KCl depolarization. MR-16728 hydrochloride also inhibits Ca(2+)-ATPase activity in pure presynaptic membranes. The half-maximal effect of MR-16728 hydrochloride occurs at a concentration of 13.5 microM. MR-16728 hydrochloride significantly enhances the release of acetylcholine in the presence of low concentrations of calcium (approximately 10 microM range). Enhanced acetylcholine release was also observed with MR-16728 hydrochloride in proteoliposomes loaded with mediator proteins[1].

O=C(NCCCN1CCCCCC1)C(C2CCCCC2)C3=CC=CC=C3.Cl

12352200