MRK-016

MedChem Express

MRK-016 [342652-67-9]

10

342652-67-9

99.71

C17H20N8O2

368.39

MRK-016 is a selective, orally bioavailable inverse agonist of GABA A alpha5 receptor , with an EC 50 of 3 nM for GABA A alpha5, and K i s of 0.83, 0.85, 0.77?and 1.4?nM for human?GABA A ?alpha1beta3gamma2, GABA A ?alpha2beta3gamma2, GABA A ?alpha3beta3gamma2, and GABA A ?alpha5beta3gamma2, respectively; MRK-016 also readily penetrates the CNS.

CN1N=CN=C1COC2=NN3C(C4=NOC(C)=C4)=NN=CC3=C2C(C)(C)C

-20°C,2°C to 8°C

12352200