MRK-016

Biorbyt

MRK-016 [342652-67-9]

16

342652-67-9

Research Use Only

C17H20N8O2

368.3931

A potent, functionally selective, CNS-penetrating and orally bioavailable inverse agonist of benzodiazepine site of GABAA alpha5 receptor with Ki of 0.8-1.5 nM for alpha1-, alpha2-, alpha3-, andalpha5-containing GABAA receptors.

CN1C(COC2C(C(C)(C)C)=C3N(C(=NN=C3)C3C=C(C)ON=3)N=2)=NC=N1

12352200