MRK-740 [2387510-80-5]

MedChem Express

MRK-740 [2387510-80-5]

10

2387510-80-5

Research Use Only

99.84

C25H32N6O3

464.56

MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50 = 0.8 microM)[1].

CC1=NC=CC(N(CC2)CCC32CN(C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)CCN3C)=C1

-20°C,2°C to 8°C

12352200