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The data was published in the journal Int J Mol Sci in 2017. PMID: 28677646
The data was published in the journal Int J Mol Sci in 2017. PMID: 28677646
The data was published in the journal Int J Mol Sci in 2017. PMID: 28677646

MRP4 antibody [M4I-10]

GTX15602
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Mouse
TargetABCC4
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Overview

  • Supplier
    GeneTex
  • Product Name
    MRP4 antibody [M4I-10]
  • Delivery Days Customer
    9
  • Application Supplier Note
    FACS: Use at a dilution of 1/20 - 1/50. ICC: Use at a dilution of 1/20 - 1/50. IHC-Fr (acetone fixed): Use at a dilution of 1/20. WB: Use at an assay dependent dilution. Predicted molecular weight: 159 kDa. Optimal dilutions/concentrations should be determined by the end user.
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    M4I-10
  • Concentration
    0.15 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10257
  • Target name
    ABCC4
  • Target description
    ATP binding cassette subfamily C member 4 (PEL blood group)
  • Target synonyms
    MOAT-B, MOATB, MRP4, ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4), canalicular multispecific organic anion transporter (ABC superfamily), multi-specific organic anion transporter B, multidrug resistance-associated protein 4
  • Host
    Rat
  • Isotype
    IgG2a
  • Protein IDO15439
  • Protein Name
    ATP-binding cassette sub-family C member 4
  • Scientific Description
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Mariscal J, Vagner T, Kim M, et al. Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles. J Extracell Vesicles. 2020,9(1):1764192. doi: 10.1080/20013078.2020.1764192
    Read this paper
  • Tsukamoto M, Yamashita M, Nishi T, et al. A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance. Cells. 2019,8(1). doi: 10.3390/cells8010039
    Read this paper
  • Tsukamoto M, Sato S, Satake K, et al. Quantitative Evaluation of Drug Resistance Profile of Cells Expressing Wild-Type or Genetic Polymorphic Variants of the Human ABC Transporter ABCC4. Int J Mol Sci. 2017,18(7). doi: 10.3390/ijms18071435
    Read this paper
  • Hazen M, Bhakta S, Vij R, et al. An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins. MAbs. 2014,6(1):95-107.
    Read this paper
  • Bebes A, Kis K, Nagy T, et al. The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related. Arch Dermatol Res. 2012,304(1):57-63. doi: 10.1007/s00403-011-1174-4
    Read this paper
  • Pelis RM, Shahidullah M, Ghosh S, et al. Localization of multidrug resistance-associated protein 2 in the nonpigmented ciliary epithelium of the eye. J Pharmacol Exp Ther. 2009,329(2):479-85. doi: 10.1124/jpet.108.149625
    Read this paper