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WB analysis of 293 cell lysate (35ug/lane) using GTX81163 MRP5 antibody, Internal.
WB analysis of 293 cell lysate (35ug/lane) using GTX81163 MRP5 antibody, Internal.
WB analysis of 293 cell lysate (35ug/lane) using GTX81163 MRP5 antibody, Internal.

MRP5 antibody, Internal

GTX81163
GeneTex
TargetABCC5
Product group Antibodies
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Overview

  • Supplier
    GeneTex
  • Product Name
    MRP5 antibody, Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000. IHC-P: 1:50-1:100. FACS: 1:10-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Gene ID10057
  • Target name
    ABCC5
  • Target description
    ATP binding cassette subfamily C member 5
  • Target synonyms
    ABC33; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; canalicular multispecific organic anion transporter C; EST277145; MOATC; MOAT-C; MRP5; multidrug resistance-associated protein 5; multi-specific organic anion transporter C; pABC11; SMRP
  • Protein IDO15440
  • Protein Name
    Multidrug resistance-associated protein 5
  • Scientific Description
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • microRNA-210 overexpression inhibits tumor growth and potentially reverses gemcitabine resistance in pancreatic cancer. Amponsah PS et al., 2017 Mar 1, Cancer Lett
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