MRPS12 Antibody

Cusabio

MRPS12 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

MRPS12

mitochondrial ribosomal protein S12

28S ribosomal protein S12, mitochondrial; mitochondrial small ribosomal subunit protein uS12m; MPR-S12; MRP-S12; MT-RPS12; RPMS12; RPS12; RPSM12; S12mt

Rabbit

IgG

28S ribosomal protein S12, mitochondrial

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5 UTR have been found for this gene; all three variants encode the same protein. Shah Z.H., Gene 204:55-62(1997). Johnson D.F., Genomics 52:363-368(1998). Ebert L., Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.

Human

-20°C or -80°C

12352203