MRS4719 [2840581-32-8]

MedChem Express

MRS4719 [2840581-32-8]

10

2840581-32-8

Research Use Only

C20H13N5O3S.C6H15N

504.60

MRS4719 is a potent P2X4 receptor antagonist with an IC50 value of 0.503 microM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke[1].

CC[NH+](CC)CC.O=C(NC1=C2C=CC=CC2=CC=C1N3C4=CC(C([N-]5)=NOC5=S)=NC=C4)CC3=O

12131703