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ProductsBack/MRTX849 ethoxypropanoic acid [2561529-98-2]

MRTX849 ethoxypropanoic acid [2561529-98-2]

HY-139403
MedChem Express
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Product group Molecular Biology
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MRTX849 ethoxypropanoic acid [2561529-98-2]
  • Delivery Days Customer
    10
  • CAS Number
    2561529-98-2
  • Certification
    Research Use Only
  • Molecular Formula
    C37H43ClFN7O5
  • Molecular Weight
    720.23
  • Scientific Description
    MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (IC50s between 0.25 and 0.76 microM)[1][2].
  • SMILES
    O=C(N1CCN(C2=C3CCN(CC3=NC(OC[C@@H]4CCCN4CCCOCCC(O)=O)=N2)C5=CC=CC6=C5C(Cl)=CC=C6)C[C@@H]1CC#N)C(F)=C
  • UNSPSC
    41115800