Chemical Structure
Chemical Structure
MS-436
82061
CAS Number1395084-25-9
Product group Chemicals
Estimated Purity98%
Molecular Weight383.4 Da
Overview
- SupplierBPS Bioscience
- Product NameMS-436
- Delivery Days Customer7
- CAS Number1395084-25-9
- CertificationResearch Use Only
- Estimated Purity98%
- Molecular FormulaC18H17N5O3S
- Molecular Weight383.4 Da
- Scientific DescriptionMS-436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM) with preference for the first bromodomain over the second. MS-436 effectively blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 microM, respectively). MS-436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression.
- Storage Instruction-20°C
- UNSPSC12352200