MS170 [2376136-61-5]

MedChem Express

MS170 [2376136-61-5]

10

2376136-61-5

Research Use Only

99.72

C45H56ClN9O7

870.44

MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively[1].

O=C1C2=C(NCCCCCCCCNC(CCNC[C@H](C3=CC=C(C=C3)Cl)C(N4CCN(C5=C6C([C@@H](C[C@H]6C)O)=NC=N5)CC4)=O)=O)C=CC=C2C(N1C7C(NC(CC7)=O)=O)=O

-20°C

12352200